Introduction to Metrics in Person Centered Medicine Research

Authors

  • Levent Kirisci Professor of Pharmaceutical Sciences and Psychiatry, University of Pittsburgh; and Co-Investigator and Director of the Statistics Core of the U.S. NIDA-funded Center for Education and Drug Abuse Research.
  • Michael Vanyukov Professor of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA.
  • Juan E Mezzich Editor in Chief, International Journal of Person Centered Medicine; Secretary General, International College of Person-centered Medicine; Professor of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.

DOI:

https://doi.org/10.5750/ijpcm.v6i4.611

Keywords:

Person-centered medicine, metrics issues, dimensionality, item response theory, bi-factor model, bayesian models, addiction

Abstract

The articulation of science and humanism is at the core of Person Centered Medicine (PCM). Thus, applying the scientific method to advance our understanding of health and the improvement of health actions towards the fulfillment of the whole person is a permanent concern of PCM.

Author Biography

Levent Kirisci, Professor of Pharmaceutical Sciences and Psychiatry, University of Pittsburgh; and Co-Investigator and Director of the Statistics Core of the U.S. NIDA-funded Center for Education and Drug Abuse Research.

I received an M.S. degree in applied statistics (1982) and M.A. and Ph.D. degrees (1985 and 1990) in mathematical and applied statistics, respectively.  Following a staff position at the University of Pittsburgh Medical School (1991-1994), I was appointed to the faculty in 1995 as Assistant Professor of Psychiatry in the University of Pittsburgh.  I was promoted to Associate Professor of Pharmaceutical Sciences and Psychiatry in 2003 and Professor in 2009.   I have been a recipient of Independent Scientist Award from U.S. National Institute on Drug Abuse (NIDA). I am also Co-Investigator and Director of the Statistics Core of the U.S. NIDA-funded Center for Education and Drug Abuse Research.  My primary expertise and research focus are devising and evaluating psychometric tools. I have been actively engaged in researching the applications of item response theory methodology and the properties of this methodology. I have spearheaded development of an interval scale to measure the psychological components of SUD liability common across the DSM-IV categories.  Employing item response theory, in conjunction with longitudinal multivariate modeling, a scale termed the liability index has been provisionally validated to quantify SUD risk at ages 10-12, 12-14, 16 and 19 in boys and girls.

References

. Mezzich JE, Kirisci L, Salloum IM (2015). Towards developing measures to assess progress towards person and people-centered care. Technical report, International College of Person Centered Medicine, New York.

. Kirisci L, Hayes JM, Mezzich JE (in press). Evaluation of person-centered health services. In J. Mezzich et al (eds.), Person-centered Psychiatry. Springer-Verlag, Heildelberg and New York.

. Falconer DS (1965). The inheritance of liability to certain diseases, estimated from the incidence among relatives. Annals of Human Genetics. 29:51-76.

. Vanyukov M, Tarter R, Kirisci L, Kirillova GP, Maher BS, Clark DB (2003). Liability to substance use disorders: 1. Common mechanisms and manifestations. Neuroscience and Biobehavioral Reviews 27: 517-526.

. Kirisci L, Tarter R, Vanyukov M, Martin C, Mezzich A, Brown S: (2006).Application of item response theory to quantify substance use disorder. Addictive Behaviors 31: 1035-1049.

. Bucholz KK, Heath AC, Reich T, Hesselbrock VM, Kramer JRNurnberger JI Jr, Schuckit MA (1996). Can we subtype? A latent class analysis of data from relatives of alcoholics in a multicenter family study of alcoholism. Alcoholism: Clinical and Experimental Research 43: 1462-1471.

. Vanyukov M, Kirisci L, Tarter R, Simkevitz HF, Kirillova GP, Maher BS: (2003). Liability to substance use disorders: 2. A measurement approach. Neuroscience and Biobehavioral Reviews 27: 507-515.

. Embretson SE, Reise, SP: (2000). Item Response Theory: Principals and Applications. Boston: Kluwer-Nijhoff Publishing.

. Vanyukov MM, Kirisci L, Moss L, Tarter RE, Reynolds MD, Maher BS, Kirillova GP, Ridenour T, Clark DB (2009) Measurement of the risk for substance use disorders: Phenotypic and genetic analysis of an index of common liability. Behav Genet 39:233–244.

Published

2017-02-02

Issue

Section

Regular Articles